Playing big unpaired hands is tricky business, and many players lose a lot of money through failing to understand how to profit long term playing these hands. Generally the first thing you have to know about big unpaired hands is that you should be folding them to a raise. Now this isn't exactly right; AK and AQ can stand up to a raise from all but the tightest players, but hands like KQ, KJ and A10 are a waste of time, generally, if you are playing them against a raise.
It has been said, and it is true, that calling a raise with K10o is worse than folding a royal flush and the logic is simple; you have to make the decision to fold or call with K10 many more times in a typical session. And by making the wrong decision all of these times you can soon become a losing player, simply by misplaying this hand.

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In late position, if there is know one in the pot or only very loose players, these hands, Ace-King, Ace-Queen, become profitable and you should raise with them. Likewise, if they are suited like AJs, it can be profitably played in large pots if there are no raises. From early position I will not play a hand worse than AQ, because you will far too often be forced into calling a raise, and then being placed into difficult spots after the flop, if you miss.
As the old saying goes, an ounce of prevention is worth a pound of cure, so dump these hands often in early position. With AK and AQ, you will want to re-raise rather then calling a bet. When your hand stands to be best it is important to get more money into the pot. This can also pot commit your opponent with a weak hand, and allow you to extract more money from him after the flop.